منابع مشابه
Current concept of neuromyelitis optica (NMO) and NMO spectrum disorders.
Neuromyelitis optica (NMO) has been described as a disease clinically characterised by severe optic neuritis (ON) and transverse myelitis (TM). Other features of NMO include female preponderance, longitudinally extensive spinal cord lesions (>3 vertebral segments), and absence of oligoclonal IgG bands . In spite of these differences from multiple sclerosis (MS), the relationship between NMO and...
متن کاملFinding NMO
Neuromyelitis optica (NMO) is a severe inflammatory demyelinating disease with lesions found primarily in the spinal cord and optic nerve. Although originally classified as a subtype of multiple sclerosis (MS), the finding of autoantibodies against the astrocyte water channel aquaporin-4 (AQ4) has defined this as a specific autoimmune disorder. Important questions have arisen as to how AQ4 anti...
متن کاملAquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO/SD
Neuromyelitis optica/spectrum disorder (NMO/SD) is a severe, inflammatory disease of the central nervous system (CNS). In the majority of patients, it is associated with the presence of pathogenic serum autoantibodies (the so-called NMO-IgGs) directed against the water channel aquaporin 4 (AQP4), and with the formation of large, astrocyte-destructive lesions in spinal cord and optic nerves. A l...
متن کاملPregnancy Management in NMO: A Case of MOG- Antibody Positive NMO and Literature Review
Neuromyelitis optica (NMO) is a rare but severely disabling disease, affecting predominantly the optic nerves and spinal cord. Aquaporin-4 (AQP4 IgG) antibodies have been described as characteristic and pathogenic for the disease. Some NMO cases are AQP4 IgG negative, of which a fraction has antibodies against myelin oligodendrocyte glycoprotein (MOG). We report the pregnancy of a 42 year old E...
متن کاملSeroprevalence of NMO-IgG Antibody in Neuromyelitis optica (NMO) and Its Specificity in Differentiating NMO from Other Demyelinating Diseases with Overlap Symptoms: An Iranian Experience.
Neuromyelitis optica is an inflammatory demyelinating disease (IDD) of the CNS, which mainly affects optic nerve and spinal cord. Autoantibodies against aquaporin-4 also known as NMO-IgG have been implicated in the pathogenesis of NMO. We evaluated the sensitivity and specificity of NMO-IgG assay for diagnosing NMO patients and differentiating them from MS patients and those with undifferentiat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuro-Ophthalmology
سال: 2013
ISSN: 1070-8022
DOI: 10.1097/wno.0b013e3182a1e6aa